Human Urine Cooling System

[Aaron Kim]

I know the title is dumb, but I was in discord with some friends and we got into an argument over whether using urine or water would be more effective for cooling a computer.

[Kanna]

Just now, Aaron Kim said:

I know the title is dumb, but I was in discord with some friends and we got into an argument over whether using urine or water would be more effective for cooling a computer.

Probably hard to tell but from knowledge water would be more effective since it’s more cool and pure *not really more pure*

[George Vella]

Honestly, as @Kannasaid, I think water would be way more effective

[ARikozuM]

Urine might be more effective, but there are proteins and salts that could grow plentiful bacteria. 

[Guest]

You could always try some Diesel Exhaust Fluid (DEF) instead of a drunk man's piss.

 

It's 70% water and 30% Urine. (Urea)

 

I'd like to see the results, please tag me for sure!!!

[Sam.MP4]

I think the water would be better because there is less acids in it maybe? You know, there is also the fact that it is human urine.

[ARikozuM]

1 minute ago, ShrimpBrime said:

It's 70% water and 30% Urine.

???

 

As opposed to iced tea which is 70% water and 30% tea? 

[Enderman]

Pretty much identical since urine is almost completely water.

[zeusthemoose]

According to this, both urine and water have the same heat capacity. This means they would both cool equally in theory. However like others have said, the other parts of urine would be bad for the loop and likely destroy it. Not to mention how bad it would smell.

[Guest]

1 minute ago, ARikozuM said:

???

 

As opposed to iced tea which is 70% water and 30% tea? 

Diesel Exhaust Fluid (DEF) is a non-hazardous solution, which is 32.5% urea and 67.5% de-ionized water. DEF is sprayed into the exhaust stream of diesel vehicles to break down dangerous NOx emissions into harmless nitrogen and water

[dizmo]

[ARikozuM]

Just now, ShrimpBrime said:

Diesel Exhaust Fluid (DEF) is a non-hazardous solution, which is 32.5% urea and 67.5% de-ionized water. DEF is sprayed into the exhaust stream of diesel vehicles to break down dangerous NOx emissions into harmless nitrogen and water

Ahh. Urea isn't urine, but now I get what you meant. 

[Letgomyleghoe]

4 minutes ago, Enderman said:

Pretty much identical since urine is almost completely water.

unless you dehydrate yourself to the point where the alkalinity has an effect on its thermodynamics.

[Matthew Lin]

6 minutes ago, ShrimpBrime said:

You could always try some Diesel Exhaust Fluid (DEF) instead of a drunk man's piss.

 

It's 70% water and 30% Urine.

 

I'd like to see the results, please tag me for sure!!!

I personally think that zebra urine would be better. It is high in androgens, which have a high heat capacity

[GiftedNovaHD]

16 minutes ago, Aaron Kim said:

I know the title is dumb, but I was in discord with some friends and we got into an argument over whether using urine or water would be more effective for cooling a computer.

Water is better. Especially pure water. It is used for industrial thermal applications and it's better than pee as it can grow bacteria and clog and reduce effectiveness

[Matthew Lin]

4 minutes ago, ARikozuM said:

Ahh. Urea isn't urine, but now I get what you meant. 

Urea is in pee, and you isolate the urea or get rid of all other chemicals in the pee by using other chemicals. So there its pee

[Guest]

1 minute ago, GiftedNovaHD said:

Water is better. Especially pure water. It is used for industrial thermal applications and it's better than pee as it can grow bacteria and clog and reduce effectiveness

 

Ice water works extremely well.

 

1 minute ago, Matthew Lin said:

I personally think that zebra urine would be better. It is high in androgens, which have a high heat capacity

Would love a read on that.

[GiftedNovaHD]

3 minutes ago, Matthew Lin said:

I personally think that zebra urine would be better. It is high in androgens, which have a high heat capacity

Yes. Androgen 

1 minute ago, ShrimpBrime said:

 

Ice water works extremely well.

 

Would love a read on that.

The androgen receptor (AR) is a ligand-activated nuclear receptor that plays a critical role in normal prostate physiology, as well as in the development and progression of prostate cancer. In addition to the classical paradigm in which AR exerts its biological effects in the nucleus by orchestrating the expression of the androgen-regulated transcriptome, there is considerable evidence supporting a rapid, nongenomic activity mediated by membrane-associated AR. Although the genomic action of AR has been studied in depth, the molecular events governing AR transport to the plasma membrane and the downstream AR signaling cascades remain poorly understood. In this study, we report that AR membrane transport is microtubule-dependent. Disruption of the function of kinesin 5B (KIF5B), but not of kinesin C3 (KIFC3), interfered with AR membrane association and signaling. Co-immunoprecipitation and pulldown assays revealed that AR physically interacts with KIF5B and that androgen enhances this interaction. Furthermore, we show that heat shock protein 27 (HSP27) is activated by membrane-associated AR and that HSP27 plays an important role in mediating AR-mediated membrane-to-nuclear signal transduction. Together, these results indicate that AR membrane translocation is mediated by the microtubule cytoskeleton and the motor protein KIF5B. By activating HSP27, membrane-associated AR potentiates the transcriptional activity of nuclear AR. We conclude that disruption of AR membrane translocation may represent a potential strategy for targeting AR signaling therapeutically in prostate cancer.

Keywords: androgen receptor, microtubule, plasma membrane, kinesin, heat shock protein (HSP), HSP27, KIF5B, prostate cancer, steroid hormone receptor, type I nuclear receptor

The androgen receptor (AR),3 along with the estrogen receptor (ER), glucocorticoid receptor (GR), progesterone receptor (PR), and the mineralocorticoid receptor (MR), is a member of the Type I nuclear receptor subfamily (1, 2). AR plays an important role in the development and maintenance of the male sexual phenotype (3, 4). Similar to other steroid hormone receptors, AR is located in the cytoplasm in the absence of androgens, forming a complex with chaperones and co-chaperones such as heat shock proteins and immunophilins (5). Upon androgen binding, AR undergoes conformational changes and translocates to the nucleus, where it binds to the androgen response elements (AREs) as a homodimer; activates the expression of AR target genes; and induces cell proliferation, differentiation, and survival (6, 7). This mode of action is the classical AR signaling pathway, also known as the genomic action. In addition to the classical pathway, many observations suggest androgens, as well as some other steroid hormones, can affect cellular processes in a nongenomic fashion (8). Cinar et al. found that within minutes of androgen stimulation, AR is localized to the membrane lipid rafts microdomain, interacts with AKT, and activates AKT signaling (9). Pedram et al. showed palmitoylation of a conserved motif in the ligand-binding domain is critical for membrane localization of estrogen receptor, progesterone receptor, and AR (10). Additionally, studies have shown AR interacts with caveolin-1 (Cav-1), a major component of the caveolae membrane structure (11, 12). Down-regulation of Cav-1 decreases AR membrane localization (11, 12). Overall, studies on membrane-associated AR are limited and very little is understood regarding the mechanisms underlying AR translocation to the plasma membrane. 

You are welcome

[MartinKweh]

First all, ew. 

 

But if you can purify it and remove the solids, it could work. Or make a similar composition with pee using chemicals (if im right its ammonia and urea but im not sure)

[Enderman]

7 minutes ago, Letgomyleghoe said:

unless you dehydrate yourself to the point where the alkalinity has an effect on its thermodynamics.

The acidity of water has negligible effect on the thermal capacity.

[Guest]

3 minutes ago, GiftedNovaHD said:

Yes. Androgen 

 Furthermore, we show that heat shock protein 27 (HSP27) is activated by membrane-associated AR and that HSP27 plays an important role in mediating AR-mediated membrane-to-nuclear signal transduction.

You are welcome

Well thank you. It was a bit more in depth perhaps than required, but yes. 

A lot of that was over by biology class studies, I feel ashamed to have read it and only understood the portion I needed to lol.

 

However this doesn't exactly tell me how much BTU a zebra urine can move.

[Aarim]

3 minutes ago, huilun02 said:

Use human blood instead

1st of all a person doing such an experiment would need to come to a conclusion about which blood they are going to use for the said purpose, i.e human sourced or animal sourced,

2nd, Lets assume this person draws his own blood, and uses it, the human blood in biologically designed to stay at 37 degree centigrade, which if exposed to normal air, rapidly Coagulates, so it will be very difficult to get it out from a persons body and put in the reservoir for circulation into the cooling system, the person doing it would require expert help .

3rd, since the biological make up of blood is such that the optimum circulation is possible at a temperature of 37 degree Celsius, and if the temperature increases more than 10% , the blood may Coagulate inside the circulation tubes, which would again heat up the processor as the designated coolant is not circulating.

4th, there will be a constant bio-hazard due to the fact that the tubing of the circulation system may corrode or a leak may occur, which in-turn may let the blood seep out into the air around and may possible be breathed by someone in close vicinity , making the environment prone to inducing deadly diseases to some other human being.

5th, as i imagine, current laws do not allow to use human blood, or blood of any other animal for such purposes, also even performing such an experiment may require special permissions from courts, depending on the nation you live in.

[Guest]

Man this is getting deep. I better go to bed.

[Matthew Lin]

3 minutes ago, GiftedNovaHD said:

Yes. Androgen 

The androgen receptor (AR) is a ligand-activated nuclear receptor that plays a critical role in normal prostate physiology, as well as in the development and progression of prostate cancer. In addition to the classical paradigm in which AR exerts its biological effects in the nucleus by orchestrating the expression of the androgen-regulated transcriptome, there is considerable evidence supporting a rapid, nongenomic activity mediated by membrane-associated AR. Although the genomic action of AR has been studied in depth, the molecular events governing AR transport to the plasma membrane and the downstream AR signaling cascades remain poorly understood. In this study, we report that AR membrane transport is microtubule-dependent. Disruption of the function of kinesin 5B (KIF5B), but not of kinesin C3 (KIFC3), interfered with AR membrane association and signaling. Co-immunoprecipitation and pulldown assays revealed that AR physically interacts with KIF5B and that androgen enhances this interaction. Furthermore, we show that heat shock protein 27 (HSP27) is activated by membrane-associated AR and that HSP27 plays an important role in mediating AR-mediated membrane-to-nuclear signal transduction. Together, these results indicate that AR membrane translocation is mediated by the microtubule cytoskeleton and the motor protein KIF5B. By activating HSP27, membrane-associated AR potentiates the transcriptional activity of nuclear AR. We conclude that disruption of AR membrane translocation may represent a potential strategy for targeting AR signaling therapeutically in prostate cancer.

Keywords: androgen receptor, microtubule, plasma membrane, kinesin, heat shock protein (HSP), HSP27, KIF5B, prostate cancer, steroid hormone receptor, type I nuclear receptor

The androgen receptor (AR),3 along with the estrogen receptor (ER), glucocorticoid receptor (GR), progesterone receptor (PR), and the mineralocorticoid receptor (MR), is a member of the Type I nuclear receptor subfamily (1, 2). AR plays an important role in the development and maintenance of the male sexual phenotype (3, 4). Similar to other steroid hormone receptors, AR is located in the cytoplasm in the absence of androgens, forming a complex with chaperones and co-chaperones such as heat shock proteins and immunophilins (5). Upon androgen binding, AR undergoes conformational changes and translocates to the nucleus, where it binds to the androgen response elements (AREs) as a homodimer; activates the expression of AR target genes; and induces cell proliferation, differentiation, and survival (6, 7). This mode of action is the classical AR signaling pathway, also known as the genomic action. In addition to the classical pathway, many observations suggest androgens, as well as some other steroid hormones, can affect cellular processes in a nongenomic fashion (8). Cinar et al. found that within minutes of androgen stimulation, AR is localized to the membrane lipid rafts microdomain, interacts with AKT, and activates AKT signaling (9). Pedram et al. showed palmitoylation of a conserved motif in the ligand-binding domain is critical for membrane localization of estrogen receptor, progesterone receptor, and AR (10). Additionally, studies have shown AR interacts with caveolin-1 (Cav-1), a major component of the caveolae membrane structure (11, 12). Down-regulation of Cav-1 decreases AR membrane localization (11, 12). Overall, studies on membrane-associated AR are limited and very little is understood regarding the mechanisms underlying AR translocation to the plasma membrane. 

You are welcome

You're thinking androgen receptors. Androgens, which are metabolized from cholesterol, keep many of the basic properties of their base molecule. As such, they are associated with higher heat capacity, and thus a better coolant as it can resist temperature changes easier.

[zeusthemoose]

Would it be possible to fill up a loop with a low-viscosity thermal paste? Would that work better than water (or urine)?