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Meet your new drug dealer: AI

Delicieuxz
By Delicieuxz
in Tech News
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AI is being used by a group of researchers at the University of British Columbia to predict what new "designer drugs" are likely to exist and emerge in the market.

 

There are hundreds or thousands of ways to get a human body to trigger a similar effect that a particular drug does, and designer drugs aim to be similar enough in their molecular composition or functionality to other popular drugs to achieve their desired effects, while being different enough in their molecular composition so as to avoid being illegal under regulation that exists against more popular and commonly-known drugs.

 

AI creates 9 million new designer drugs

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Scientists have used artificial intelligence to "predict" formulas for new designer drugs, with the stated goal of helping to improve their regulation. The AI generated formulas for nearly nine million potential new drugs.
Researchers with the University of British Columbia (UBC) used a deep neural net for the job, teaching it to make up chemical structures of potential new drugs. According to their study, released this week, the computer intelligence fared better at the task than the scientists had expected.

 

The research team used a database of known designer drugs – synthetic psychoactive substances – to train the AI on their structures. The market for designer drugs is ever-changing, since their manufacturers are constantly tweaking their formulas to circumvent restrictions and produce new "legal" substances, while cracking their structure takes months for law enforcement agencies, the researchers said.

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"The vast majority of these designer drugs have never been tested in humans and are completely unregulated. They are a major public-health concern to emergency departments across the world," one of the researchers, UBC medical student Dr. Michael Skinnider has said.

 

After its training, the AI was able to generate some 8.9 million potential designer drugs. Afterwards, researchers ran a data sheet of some 196 new drugs, which had emerged in real life after the model was trained, and found that more than 90% of these have been already predicted by the computer.

 

A deep generative model enables automated structure elucidation of novel psychoactive substances

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Over the past decade, the illicit drug market has been reshaped by the proliferation of clandestinely produced designer drugs. These agents, referred to as new psychoactive substances (NPSs), are designed to mimic the physiological actions of better-known drugs of abuse while skirting drug control laws.

 

This is what happens when technology falls into the wrong hands: They try to use it to increase drug regulation!

 

Well, interesting that there are that many analogues to popular drugs. Maybe they can use AI to find some which mitigate the health risks of other drugs, whether they're legal or illegal.

You own the software that you purchase - Understanding software licenses and EULAs

 

"We’ll know our disinformation program is complete when everything the american public believes is false" - William Casey, CIA Director 1981-1987

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Damn at first I thought this was a step towards the omniverse. I predict once we have an interface with neurolink with our brains we'll have software or firmware based drugs. You'll be able to directly fine tune the chemicals to create whatever you want and then sell the firmware bundle. The price will reflect the complexity of the code and the understanding the programmer has of the software brain interaction. I wonder if it will create virtual dependencies? But then we would have the control to never have a dependencies or withdrawal. 

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Just keeping this here as a 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This is not AI being used to preemptively make drugs illegal before they exist (or even discovering new ones (with regards the jacs paper)).
It is being used to try and get a structure of a molecule using only one instrument in tandem with an AI model to help analyse the data. (Figuring out a structure is hard, and usually requires a battery of instruments - this is where the novelty of this paper lies). 
 

Structure and activity are so hard to guess: look at the difference between heroin and fentanyl.
A24B1630-3E68-4D60-93DD-9FE5965DEC2B.thumb.jpeg.73cd99b054fa8eae7905c5ca0e3c5117.jpeg

 

It would be hard to guess at first sight that they act similarly. Yet I think we can argue that it's a good idea they're both being controlled, despite their considerably different structures. 

Bleigh!  Ever hear of AC series? 

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On 11/24/2021 at 4:54 PM, Not_A_Spider said:

So the AI thnks up psychoactive drugs for the sole purpose of pre-emptively making them illegal?

 

 

Pretty much and it's been demonstrated time after time making a drug illegal makes it impossible for people to use....oh wait

▓ƆԀ▓ S▓₱▓Ɇ▓c▓s▓: i7 6ʇɥפᴉƎ00K (4.4ghz), Asus DeLuxe X99A II, GT҉X҉1҉0҉8҉0 Zotac Amp ExTrꍟꎭe),Si6F4Gb D???????r PlatinUm, EVGA G2 Sǝʌǝᘉ5ᙣᙍᖇᓎᙎᗅᖶt, Phanteks Enthoo Primo, 3TB WD Black, 500gb 850 Evo, H100iGeeTeeX, Windows 10, K70 R̸̢̡̭͍͕̱̭̟̩̀̀̃́̃͒̈́̈́͑̑́̆͘͜ͅG̶̦̬͊́B̸͈̝̖͗̈́, G502, HyperX Cloud 2s, Asus MX34. פN∩SW∀S 960 EVO

Just keeping this here as a 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Kids, this is why you shouldn't do AI drugs.

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when they start producing metabolism boosters so i don't have to waste time in a gym every week, sign me up yesterday.

The best gaming PC is the PC you like to game on, how you like to game on it

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11 hours ago, GhostRoadieBL said:

when they start producing metabolism boosters so i don't have to waste time in a gym every week, sign me up yesterday.

The candle that burns twice as bright burns half as long. As cells divide, the telomeres shorten. It's why people that smoke, drink, do narcotics will burn through their cells and replacements quickly that they physically age faster.

 

Drugs that mess with hormones seems to be a precarious situation where you solve for one problem, but end up causing others down the road.

 

Intermittent fasting would be the least harmful over designer drugs.

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On 11/24/2021 at 10:57 AM, BuckGup said:

Damn at first I thought this was a step towards the omniverse. I predict once we have an interface with neurolink with our brains we'll have software or firmware based drugs. You'll be able to directly fine tune the chemicals to create whatever you want and then sell the firmware bundle. The price will reflect the complexity of the code and the understanding the programmer has of the software brain interaction. I wonder if it will create virtual dependencies? But then we would have the control to never have a dependencies or withdrawal. 

Matrix anyone?

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On 11/24/2021 at 5:54 PM, Not_A_Spider said:

So the AI thnks up psychoactive drugs for the sole purpose of pre-emptively making them illegal?

 

 

That may be today's official stance, yes.

 

In due time, when governments seek cost-effective ways to keep their populace pacified (bread, circuses, and opioids), the data and the "solutions" this provides will prove quite convenient 😉.

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Drug dealers can't wait to get prediction software of such sort so they'll know exactly what kind of products they need to make, in what form and how strong.

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5 hours ago, RejZoR said:

Drug dealers can't wait to get prediction software of such sort so they'll know exactly what kind of products they need to make, in what form and how strong.

Well you see this isn't actually useful for drug dealers as they don't have massive chem laboratories and access to any chemicals they want. This is more for head shops and companies as they skate the grey market to reap the profits. It's what happened with THC Delta 8. THC Delta 9 is illegal but 8 is more medicinal so it's not illegal. They both still get you high. It's like spice

▓ƆԀ▓ S▓₱▓Ɇ▓c▓s▓: i7 6ʇɥפᴉƎ00K (4.4ghz), Asus DeLuxe X99A II, GT҉X҉1҉0҉8҉0 Zotac Amp ExTrꍟꎭe),Si6F4Gb D???????r PlatinUm, EVGA G2 Sǝʌǝᘉ5ᙣᙍᖇᓎᙎᗅᖶt, Phanteks Enthoo Primo, 3TB WD Black, 500gb 850 Evo, H100iGeeTeeX, Windows 10, K70 R̸̢̡̭͍͕̱̭̟̩̀̀̃́̃͒̈́̈́͑̑́̆͘͜ͅG̶̦̬͊́B̸͈̝̖͗̈́, G502, HyperX Cloud 2s, Asus MX34. פN∩SW∀S 960 EVO

Just keeping this here as a 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1 hour ago, BuckGup said:

Well you see this isn't actually useful for drug dealers as they don't have massive chem laboratories and access to any chemicals they want. This is more for head shops and companies as they skate the grey market to reap the profits. It's what happened with THC Delta 8. THC Delta 9 is illegal but 8 is more medicinal so it's not illegal. They both still get you high. It's like spice

Lol, you watch too many movies where there is one junky cooking something in his shed house. Reality is, cartels have entire production lines where they manufacture drugs in massive quantities.

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So, this isn't my particular niche of chemistry, but it's one of the fields I've read into and am really excited by nonetheless.

 

As someone who typically relies on experimental X-ray crystallography to elucidate structures stuff like this is actually really exciting. I've always described being able to visualize the actual structure of molecules experimentally as black magic, and, well, it kinda is black magic even to experts in the field. Being able to computationally elucidate structures from limited experimental data is a massive novelty in itself, scientifically, even if its accuracy is only 86%. I have access to software that attempts to reverse-engineer structures from spectroscopic data, but I never end up using it because the results it puts out are garbage (never mind the concerns of it effectively being a proprietary black box).

 

A more mainstream application of ML to chemistry has been its use to generate target molecules that would be good drug candidates for certain pharmaceutical problems. The model paper I find the most fascinating in its methodology is probably this Nature paper from 2019 that wanted to target DDR1 kinase inhibitors (don't know what a DDR1 kinase inhibitor is? Neither do I, but the paper is still fascinating nonetheless).

It's entirely possible that I misinterpreted/misread your topic and/or question. This happens more often than I care to admit. Apologies in advance.

 

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4 hours ago, BuckGup said:

Well you see this isn't actually useful for drug dealers as they don't have massive chem laboratories and access to any chemicals they want. This is more for head shops and companies as they skate the grey market to reap the profits. It's what happened with THC Delta 8. THC Delta 9 is illegal but 8 is more medicinal so it's not illegal. They both still get you high. It's like spice

rrrrrrrrrrrrrrrrrrrriiiiighhhhhhhttttttttt

and cartel don't exist and they do not control entire countries 

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As technology advances, it becomes cheaper, smaller, and more easily accessible. Maybe one day there will be machines that people might be able to have in their homes which will be able to automatically produce compounds of whatever molecular structures people want them to.

 

Then again, maybe before that time arrives, more advanced or privileged groups with access to such technology will have already used it to create biological weapons that end up wiping all humans out.

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20 hours ago, suicidalfranco said:

rrrrrrrrrrrrrrrrrrrriiiiighhhhhhhttttttttt

and cartel don't exist and they do not control entire countries 

I wouldn't underestimate the grey market. Many have moral conflicts or simply don't want to be arrested so by purchasing a legal substance through a legitimate store they can still get their fix legally and conveniently. 

▓ƆԀ▓ S▓₱▓Ɇ▓c▓s▓: i7 6ʇɥפᴉƎ00K (4.4ghz), Asus DeLuxe X99A II, GT҉X҉1҉0҉8҉0 Zotac Amp ExTrꍟꎭe),Si6F4Gb D???????r PlatinUm, EVGA G2 Sǝʌǝᘉ5ᙣᙍᖇᓎᙎᗅᖶt, Phanteks Enthoo Primo, 3TB WD Black, 500gb 850 Evo, H100iGeeTeeX, Windows 10, K70 R̸̢̡̭͍͕̱̭̟̩̀̀̃́̃͒̈́̈́͑̑́̆͘͜ͅG̶̦̬͊́B̸͈̝̖͗̈́, G502, HyperX Cloud 2s, Asus MX34. פN∩SW∀S 960 EVO

Just keeping this here as a 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Posted
23 hours ago, RejZoR said:

Lol, you watch too many movies where there is one junky cooking something in his shed house. Reality is, cartels have entire production lines where they manufacture drugs in massive quantities.

Right but that's not what I am talking about. 

▓ƆԀ▓ S▓₱▓Ɇ▓c▓s▓: i7 6ʇɥפᴉƎ00K (4.4ghz), Asus DeLuxe X99A II, GT҉X҉1҉0҉8҉0 Zotac Amp ExTrꍟꎭe),Si6F4Gb D???????r PlatinUm, EVGA G2 Sǝʌǝᘉ5ᙣᙍᖇᓎᙎᗅᖶt, Phanteks Enthoo Primo, 3TB WD Black, 500gb 850 Evo, H100iGeeTeeX, Windows 10, K70 R̸̢̡̭͍͕̱̭̟̩̀̀̃́̃͒̈́̈́͑̑́̆͘͜ͅG̶̦̬͊́B̸͈̝̖͗̈́, G502, HyperX Cloud 2s, Asus MX34. פN∩SW∀S 960 EVO

Just keeping this here as a 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Posted

I don't have a drug dealer, can I have one now?

I edit my posts more often than not

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13 hours ago, BuckGup said:

I wouldn't underestimate the grey market. Many have moral conflicts or simply don't want to be arrested so by purchasing a legal substance through a legitimate store they can still get their fix legally and conveniently. 

and many have no morals and will take out who ever dares to eat their crumbs by any means necessary

One day I will be able to play Monster Hunter Frontier in French/Italian/English on my PC, it's just a matter of time... 4 5 6 7 8 9 years later: It's finally coming!!!

Phones: iPhone 4S/SE | LG V10 | Lumia 920 | Samsung S24 Ultra

Laptops: Macbook Pro 15" (mid-2012) | Compaq Presario V6000

Other: Steam Deck

<>EVs are bad, they kill the planet and remove freedoms too some/<>

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