USB devices preventing X370 Crosshair VI Hero from powering on

[Voxels-Box]

Full PC specs here

Main specs:
AMD 1700X
Asus Crosshair VI Hero
Asus GTX 1080 ti
Corsair DDR4 3000 4x8gb
Windows 10

 

So last night while getting started at the computer, I tapped the keyboard to wake it up, and then plugged in my USB flash drive, which may have caused the system to power down completely. I thought it went back to sleep, but after plugging in the drive, it never woke back up. The only light on the mobo was the red indicator light at the bottom right.

 

I went through the usual troubleshooting, and found that it I unplugged all USB devices from the mobo, it was able to turn back on.
I then plugged devices back in, and it seemed to work.
This morning, my fiancee went to go play games and the same problem occurred again.
I unplugged the ethernet, usb 3.1 Gen 2 Type A (to a powered 7 port USB hub) and the USB 3.1 gen 2 Type C (goes to a 4 port USB C hub)
It worked after unplugging those items. I then left for work, so I dont know if the issue has repeated, but it seems likely.
Could plugging in my flash drive while the PC was starting up caused a problem?
Any suggestions for resolving this and preventing it from happening again.

Notes: I have a ton of USB devices and all USB ports on the motherboard are utilized. Devices used: Corsair K70 rgb, Wacom tablet, Senheisser DAC, Scarlet Solo, card reader, a couple phone cables, a usb2.o to usb2.0 internal header, and a few other things. The wireless dongles for the mouse and a spare wireless keyboard are connected to the 4 port USB 3.1 Type C hub.

Thank you!

[Fasauceome]

this is extremely peculiar, and seems like a familiar problem I had. I'll have to experiment on my own rig, and see if I can get anything useful out of it.