Case pressure: Positive or Negative
This is really controversial and sometimes it has so many variables apart from what case you're using... I really recommend reading this thread as it helped me a lot and changed my mind on somethings I believed.
So, usually, negative pressure you have better temperatures as the hot air gets out from the case faster, as long as you have enough supply of fresh air. However, any cracks/gaps/holes on your case will be sucking air (read dust because there are no filters for cracks) in to try to compensate for the pressure inside the case.
Positive pressure, on the other hand, takes more time to exhaust the hot air from the case, having slightly better temperatures for short usage time and getting hotter on longer use. I'm not saying 10ºC difference, just about 2~3ºC usually. If not made properly, sometimes the intakes can be disrupting each other making hot bubbles in the GPU/CPU areas. However, it's the opposite of negative pressure regarding cracks as they will always be exhausting air, instead of sucking, to try to compensate for the pressure inside the case.
Either way, always have your intakes filtered. It's a good trade off for a slightly worse fan performance.
Now, to make the best choice, there's nothing better than experimenting. If you live at a dusty place, positive is probably the best idea. If you live at a hot place, without AC, negative might be the way to go. In either way, experimenting with fan layouts and pressure is the best thing to do.
Also, when I say negative/positive pressure, I mean a slight difference in CFM, not something HUGE. The best is to have "normal pressure" but it's rather difficult.
The setup I'll be doing on my rig is to have (slightly) positive pressure while on idle and, when the system is under load, a fan will spin faster so I have negative when I need the "best" temperatures. I'll copy this from a fellow forum member and the results seem to be really good.
P.S.: I do not have a way to prove this numbers/facts, it's just the opinion/knowledge I acquired after experimenting a bit with my old case and reading a lot of texts about this.

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