That's just about the fastest CPU it can take. The only other options are the 4770K (Just an overclockable 4770) or the 4790 and 4790k, which are 'ever so slightly faster' and 'ever so slightly faster and also overclockable'. So, really? No. For the costs involve you'd make the CPU negligibly faster, it'd be a nearly lateral upgrade.
Graphics, well, that's a big wild card. You can put anything in there. Wanna drop $2000 on an RTX 3090? That'll fit. Might be a bit lopsided performance wise but it'd kick ass.