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How do u delete Windows Defender mpcache files?

Hi, in one of our computers the C:\ProgramData\Microsoft\Windows Defender\Scans folder consists of a bunch of mpcache files that add upto around 10gb. I would like to delete them as it is consuming too much space. Tried deleting them manually but I get the error saying Windows Defender Service is using this file and it cannot be deleted. I noticed that even if I turn off Windows Defender from settings, it doesn't allow the files to be deleted. Also noticed that the Defender service cannot be stopped in the services Window as the options are greyed out. Some insight to get this done would be really helpful. Thanks. 

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That's one of the choices in the Disk Cleanup wizard.

F@H
Desktop: i9-13900K, ASUS Z790-E, 64GB DDR5-6000 CL36, RTX3080, 2TB MP600 Pro XT, 2TB SX8200Pro, 2x16TB Ironwolf RAID0, Corsair HX1200, Antec Vortex 360 AIO, Thermaltake Versa H25 TG, Samsung 4K curved 49" TV, 23" secondary, Mountain Everest Max

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GPD Win 2

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15 hours ago, Kilrah said:

That's one of the choices in the Disk Cleanup wizard.

I see. After some searching I managed to find a solution. I had to install a third party software to disable Windows defender and stop the service until I delete the mpcache files manually. Got it done this way.

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