Open Loop Orientation Doesn't Matter.
While there is a delta between radiator in- and outlet, that delta is pretty low and it depends on the flowrate. The lower the flowrate, the higher the delta. The actual delta depends on the specifics of each loop however expect something in the range of ~0.2-2K difference in water temps. That delta does not directly result in the same difference on your CPU block. Of course, having a little bit colder water will result in a more efficient heat transfer between CPU block and water, however the bottleneck is not really the transfer between block and water but both between Die and IHS and between IHS and block (smallest contact area in both cases).
The impact of flowrate on the delta between in- and outlet does not mean, that slower flowrates are better (or vice versa for the blocks). Overall the total amount of heat energy being transferred is about the same. Basically (and very simplified), if you'd trace a water molecule through the loop it might remain in contact with the radiator surface for a shorter amount of time each round when flowrate is high, BUT it will do more rounds in the same amount of time as it would with a lower flowrate. The total amount of energy that is being dissipated through the radiator will be basically the same.
Of course, the type of flow (i.e. turbulent vs laminar) has an impact but our regular pumps will usually not easily make flow switch between those states. It is more dependant on the design of the specific component.
The difference in CPU (or GPU) temps will be marginal and within the margin of error. I'd dare to say a random Windows background process will have a larger effect on your temps and regulating/controlling your ambient temperature will be more beneficial in real world applications.
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