Do you see any issues?
For the most part, looks very solid.
If you want a different option from the other side of the fence:
PCPartPicker part list / Price breakdown by merchant
CPU: Intel - Core i7-8700K 3.7GHz 6-Core Processor ($414.89 @ B&H)
CPU Cooler: NZXT - Kraken X52 Rev 2 73.1 CFM Liquid CPU Cooler ($139.89 @ OutletPC)
Motherboard: Asus - ROG STRIX Z370-E GAMING ATX LGA1151 Motherboard ($197.99 @ SuperBiiz)
Memory: Corsair - Vengeance LPX 16GB (2 x 8GB) DDR4-3200 Memory ($200.11 @ Newegg Marketplace)
Storage: Samsung - 960 EVO 1TB M.2-2280 Solid State Drive ($435.99 @ Amazon)
Video Card: EVGA - GeForce GTX 1080 Ti 11GB SC Black Edition Video Card ($743.99 @ SuperBiiz)
Case: Phanteks - ECLIPSE P400S TEMPERED GLASS ATX Mid Tower Case ($84.99 @ Amazon)
Power Supply: EVGA - SuperNOVA P2 850W 80+ Platinum Certified Fully-Modular ATX Power Supply ($103.98 @ Newegg)
Monitor: BenQ - GW2270 21.5" 1920x1080 60Hz Monitor ($79.00 @ Amazon)
Monitor: Acer - Predator XB1 27.0" 2560x1440 165Hz Monitor ($449.99 @ B&H)
Keyboard: Corsair - K65 RGB Wired Gaming Keyboard ($89.99 @ Amazon)
Total: $2940.81
Prices include shipping, taxes, and discounts when available
Generated by PCPartPicker 2017-11-15 14:48 EST-0500
Swapped out the PSU for a larger one so you could expand in the future if needed and still have OC headroom but you can drop it back to a 650 if you don't think another GPU will be added. Other than that I did pick out a board with wireless built in and cut out the extra card. Obviously that was for this build option and if you go with Ryzen maybe see if there is a board with built-in wifi as well.

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