Best performance setup for installing RAM?
For Prime95 large FFT and similar workloads:
Joint best: 4x4 GB single rank, or 2x8 GB dual rank modules, running dual channel. On most mobos with 4 ram slots, positions 2 and 4 are recommended.
Intermediate: 2x8 GB single rank, dual channel.
Big bag of NOPE: 1x16 GB or 2x8 GB on single channel. You're just throwing away bandwidth and performance here...
In my testing dual rank per channel of the same speed and timings gives up to 20% performance boost in memory intensive bandwidth limited work compared to single rank per channel. It doesn't seem to matter if dual rank modules are used, or two single rank.
In synthetic benchmarks like Aida64, dual rank over single gives a slight increase in bandwidth, but also a slight increase in latency. Certainly not of the magnitude in the improvement observed. Also latency seems to have a much smaller influence than rawr speed so given the choice, I'd prioritise a dual channel dual rank kit as fast as reasonably possible (don't over-pay for it), with latency down the list. For DDR4, 4GB modules are single rank. 8 GB can go either way, with faster and/or tighter timing kits tending towards single.
Similar applies to quad channel ram, but you have to consider the ram speed proportionate to the total CPU demand it is supplying. More cores at more clock means you should ideally consider faster ram to keep up with it.
I go into this in a bit more detail in following thread:

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