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Can you use two Nvidia GPU's of different branding and dedicate one of them to PhysX on OSX? I know that you can do it on windows, but I would like to use a GTX 760 as my main, and then let a 650Ti Boost do all the PhysX. Is this doable in OSX?

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You cannot have a PhysX card nor SLI in OSX AFAIK. However, you can use different brand of cards for SLI and PhysX.

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sli and physx is blasphemy in the book of Jobs

I'm actually reading the book. I guess I haven't gotten there yet.

My Build Log on PCPartPicker FX-6300, ASUS M5A78L-M/USB3, MSI 7870 GHz Edition, Corsair Vengeance LP 1x8GB, 1TB WD Blue, Fractal Core 1000 USB 3.0, Corsair CX600, and my most recent addition that I've had forever and isnt new is a 80GB WD800 for Linux, Lenovo ThinkPad X131e, ASUS Transformer TF300T, Galaxy Note 3 Sister dropped it in a puddle I now have to use a Samsung Brightside, Beyerdynamic DT990 Pro 250ohm version, Blue Yeti  #TheRealKEH-JEFF | "Sometimes, if were lucky, in Australia, a family has 2 kangaroos to pick up the kids with" - marto | Your entry here | Remember kids; just because Linus has a video on it, doesn't mean that its the best choice | ts3.wferr.com the best TeamSpeak Abide by the CoC | Looking for build help? Read this before posting |
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