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I'm pretty sure you can but I've heard from somewhere that Nvidia drivers crap themselves when they detect an instance of CCC running.. may just be a false statement...

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Well i heard that nvidia cards and amd cards don't work well together , but you should be fine.

AMD Ryzen R7 1700 (3.8ghz) w/ NH-D14, EVGA RTX 2080 XC (stock), 4*4GB DDR4 3000MT/s RAM, Gigabyte AB350-Gaming-3 MB, CX750M PSU, 1.5TB SDD + 7TB HDD, Phanteks enthoo pro case

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You can run two monitors from one card.

CPU: i7 3770K | MB: EVGA Z77 FTW | RAM: HyperX Savage 2400Mhz 16GB | GPU: R9 280X Toxic | Cooler: Scythe Fuma | PSU: CoolerMaster B600

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Hello, is it possible to run an MSI Radeon R7 250X graphics card with a GTX 480 graphics card in the same system without using SLI or crossfire to run two different monitors?

 

Sure but you can run multiple monitors off one graphics card with no penalty

Desktop - Corsair 300r i7 4770k H100i MSI 780ti 16GB Vengeance Pro 2400mhz Crucial MX100 512gb Samsung Evo 250gb 2 TB WD Green, AOC Q2770PQU 1440p 27" monitor Laptop Clevo W110er - 11.6" 768p, i5 3230m, 650m GT 2gb, OCZ vertex 4 256gb,  4gb ram, Server: Fractal Define Mini, MSI Z78-G43, Intel G3220, 8GB Corsair Vengeance, 4x 3tb WD Reds in Raid 10, Phone Oppo Reno 10x 256gb , Camera Sony A7iii

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Is it possible? Yes.

Should you? Probably not

i5-4690k @ 4.2GHz | Asus Radeon R9 290 DirectCU II | Hyper 212 EVO | ASRock Z97 Extreme3 | Corsair Vengeance 8GB 1866MHz, Corsair XMS 4GB | 850 EVO 250GB, random 1TB drive | Corsair 200R | EVGA SuperNOVA 750W | Rosewill RK-9000BR | Logitech G700s | Logitech G930 | ViewSonic VG2427wm, Dell S2209W, Dell S2009W

Dell Inspiron 3147

Latitude E5420, Samsung 840 EVO 250gb, 12gb RAM, 1600x900 display

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