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With AMD GPUs as long as they are the same core you can crossfire them.

7970, 7950, 7870 XT, 280 and 280X can all be Crossfired together because all five are Tahiti.

Rule of thumb with AMD GPUs for crossfire is if they are the same second number (7950, 7950, 280, 280X) you can crossfire them.  There are a couple exceptions like the previously mention 7870XT (really should have just been called 7930).

 

Different brands don't matter as long as they are the same core, clock speed doesn't matter but vRAM does, if you have a 2GB and a 4GB card you will be limited to 2GB when in crossfire.

 

Just for fun

SLI for Nvidia GPUs are really locked down. You can only SLI multiple GPUs that are exactly the same, so you can only SLI a 660Ti with another 660Ti. Recently Nvidia has relaxed the restriction slightly so you can run multiple cards at different clock speeds. Like with AMD Crossfire if you have cards of multiple vRAM amounts like a 2GB 960 and a 4GB 960 only 2GB will be usable. Also Nvidia SLI requires at least an 8x PCIe lane, so unless you are on 2011 you can only do dual SLI. AMD Crossfire only needs a 4x PCIe lane, so for Tri/Quad Crossfire you can do that on mainstream chipsets like Z97.

 

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As mentioned, brand does not matter. As long as the GPU core is the same, you can run them in Crossfire.

In your case, you can Crossfire any of the following with your R9-270X

  • R9-270X
  • R9-270 (downclocked version of the 270X)
  • R9-265 (same GPU core as the 270/270X, but the number of Stream Processors is cut down)

The R9-265 and R9-270(X) is similar to the R9-280 and the R9-280X....or the HD 7950 and the HD 7970.

 

The two graphics cards does not need to run at the same frequencies. One can be slower/faster than the other. If your overclocking software has the option (like Sapphire TriXX), you can make the cards run synchronized -- both at the same set frequencies that you set.

 

I have that option unchecked, and my two HD 7970's can run at their own separate Core & Memory frequencies.

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