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Yes you sure can. That's basically Tri-CFX.

 

FOR THE LOVE OF GOD DON'T GET THE STOCK R9 290X. Get the PowerColor one (Downclock if needed).

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FORMERLY FANBOY OF: A-Data, Corsair, Nvidia

DEVELOPING FANBOY OF: AMD (GPUS), Intel (CPUs), ASRock

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I want to know if it's possible to run a R9 290X and a R9 295X2 in the same system?

Yes, and all three GPUs can be run together in CrossFire

 

http://www.hardocp.com/article/2014/05/13/amd_radeon_r9_295x2_xfx_290x_dd_trifire_review/#.VOqviarF-So

"Rawr XD"

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Definitely. They will both work in CrossFire, get a good cooler though. The Tri-X and PCS+ are both very good.

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