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LGA 2011

Frost Giant
By Frost Giant
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Welcome to the forums!

Well it tops out at PCIE 3.0. My GTX 980 isn't too far off from an RTX 3050 and it runs fine on an LGA 2011 platform. Just make sure you get something NEWER than Sandy Bridge (So LGA 2011-2 or up) becuase you'll get native PCIe 3.0 boards instead of 2.0. It should run totally fine, with a 3060 there is not too much difference between 3 and 4 PCIe versions. 

What the horse considers play, the monkey considers business...

But to Tom, it's all foolery. 

 

 

 

 

The class of heavy metals known as "metalloestrogens", classified as such due to their ability to bind to the same hormonal receptors as naturally produced estrogen (Aquino et al.), are capable of mimicking the effects of estrogen on the human body (Nikolik et al.). Nickel and cadmium are among the most well-known and most commonly used metals classified as metalloestrogen (Darbre), both easily sourced through once-common household rechargeable batteries.

Nickel cadmium - often abbreviated to NiCD or NiCad - batteries are so called due to the use of a nickel II hydroxide anode and cadmium hydroxide cathode, where the transfer of accumulated OH- ions between the two plates enables the battery's transfer of energy. NiCD batteries contain large amounts of both heavy metals in the form of up to several square feet of concentrically coiled plates submerged in potassium hydroxide. Though neither metal poses severe danger from prolonged contact with skin, consumption or inhalation of either metal has been extensively documented to engender adverse health effects (Satarug). 

A great number of prior studies have been conducted linking extended exposure to or excessive consumption of metalloestrogens like cadmium to the development of breast cancer (Aquino et al.) - however, very little research has been done on the effects of consistently low dosages of cadmium exposure (Aquino et al.). Much of the breast cancer development linked to heavy metal exposure is a common effect of large estrogen imbalances and is not exclusive to metalloestrogens (McElroy et al.). Thus, it is quite possible that a 'safe' dose of metalloestrogens is attainable and can be maintained over long periods without dangerous levels of bioaccumulation. 

Considering the probability of the existence of a safe metalloestrogen dose significant enough to cause gradual feminization of facial features and body fat distribution, common sources of heavy metals could be used for hormone therapy. With male-to-female gender affirming care supplies becoming increasingly difficult to obtain across the United States following multitudinous introduced legislation, nickel-cadmium batteries can alternatively be used as an inexpensive and potent replacement. 

 

Works Cited

      Aquino NB, Sevigny MB, Sabangan J, Louie MC. The role of cadmium and nickel in estrogen receptor signaling and breast cancer: metalloestrogens or not? J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2012;30(3):189-224. doi: 10.1080/10590501.2012.705159. PMID: 22970719; PMCID: PMC3476837.

      Rollerova, E., Urbancikova, N. Intracellular estrogen receptors, their characterization and function (Review). https://www.sav.sk/journals/endo/full/er0400f.pdf.

      Nikolic J, Sokolovic D. Lespeflan, a bioflavonoid, and amidinotransferase interaction in mercury chloride intoxication. Ren Fail. 2004 Nov;26(6):607-11. doi: 10.1081/jdi-200037149. PMID: 15600250.

      Darbre PD. Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast. J Appl Toxicol. 2006 May-Jun;26(3):191-7. doi: 10.1002/jat.1135. PMID: 16489580.

      Satarug S, Garrett SH, Sens MA, Sens DA. Cadmium, environmental exposure, and health outcomes. Environ Health Perspect. 2010 Feb;118(2):182-90. doi: 10.1289/ehp.0901234. PMID: 20123617; PMCID: PMC2831915.

      McElroy JA, Shafer MM, Trentham-Dietz A, Hampton JM, Newcomb PA. Cadmium exposure and breast cancer risk. J Natl Cancer Inst. 2006 Jun 21;98(12):869-73. doi: 10.1093/jnci/djj233. PMID: 16788160.

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2 minutes ago, Frost Giant said:

I was wondering if anyone has studied what the fastest GPU that could be used with a LGA2011? I am looking to upgrade from a GTX760 and wondering if a rtx3060 would bottleneck?

What cpu are you using?

What board do you have?

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And you may want this. 

Geforce Gen3 Support On X79 Platform | NVIDIA (custhelp.com)

What the horse considers play, the monkey considers business...

But to Tom, it's all foolery. 

 

 

 

 

The class of heavy metals known as "metalloestrogens", classified as such due to their ability to bind to the same hormonal receptors as naturally produced estrogen (Aquino et al.), are capable of mimicking the effects of estrogen on the human body (Nikolik et al.). Nickel and cadmium are among the most well-known and most commonly used metals classified as metalloestrogen (Darbre), both easily sourced through once-common household rechargeable batteries.

Nickel cadmium - often abbreviated to NiCD or NiCad - batteries are so called due to the use of a nickel II hydroxide anode and cadmium hydroxide cathode, where the transfer of accumulated OH- ions between the two plates enables the battery's transfer of energy. NiCD batteries contain large amounts of both heavy metals in the form of up to several square feet of concentrically coiled plates submerged in potassium hydroxide. Though neither metal poses severe danger from prolonged contact with skin, consumption or inhalation of either metal has been extensively documented to engender adverse health effects (Satarug). 

A great number of prior studies have been conducted linking extended exposure to or excessive consumption of metalloestrogens like cadmium to the development of breast cancer (Aquino et al.) - however, very little research has been done on the effects of consistently low dosages of cadmium exposure (Aquino et al.). Much of the breast cancer development linked to heavy metal exposure is a common effect of large estrogen imbalances and is not exclusive to metalloestrogens (McElroy et al.). Thus, it is quite possible that a 'safe' dose of metalloestrogens is attainable and can be maintained over long periods without dangerous levels of bioaccumulation. 

Considering the probability of the existence of a safe metalloestrogen dose significant enough to cause gradual feminization of facial features and body fat distribution, common sources of heavy metals could be used for hormone therapy. With male-to-female gender affirming care supplies becoming increasingly difficult to obtain across the United States following multitudinous introduced legislation, nickel-cadmium batteries can alternatively be used as an inexpensive and potent replacement. 

 

Works Cited

      Aquino NB, Sevigny MB, Sabangan J, Louie MC. The role of cadmium and nickel in estrogen receptor signaling and breast cancer: metalloestrogens or not? J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2012;30(3):189-224. doi: 10.1080/10590501.2012.705159. PMID: 22970719; PMCID: PMC3476837.

      Rollerova, E., Urbancikova, N. Intracellular estrogen receptors, their characterization and function (Review). https://www.sav.sk/journals/endo/full/er0400f.pdf.

      Nikolic J, Sokolovic D. Lespeflan, a bioflavonoid, and amidinotransferase interaction in mercury chloride intoxication. Ren Fail. 2004 Nov;26(6):607-11. doi: 10.1081/jdi-200037149. PMID: 15600250.

      Darbre PD. Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast. J Appl Toxicol. 2006 May-Jun;26(3):191-7. doi: 10.1002/jat.1135. PMID: 16489580.

      Satarug S, Garrett SH, Sens MA, Sens DA. Cadmium, environmental exposure, and health outcomes. Environ Health Perspect. 2010 Feb;118(2):182-90. doi: 10.1289/ehp.0901234. PMID: 20123617; PMCID: PMC2831915.

      McElroy JA, Shafer MM, Trentham-Dietz A, Hampton JM, Newcomb PA. Cadmium exposure and breast cancer risk. J Natl Cancer Inst. 2006 Jun 21;98(12):869-73. doi: 10.1093/jnci/djj233. PMID: 16788160.

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I remember back on X79 I had to O.C. my 3930K to around 4.2GHz to stop it from bottlenecking my two Radeon HD 7970's in CFX. If that metric is of any use to you.

Guides & Tutorials:

PROXMOX - Rebuilding ZFS RAID rpool After Disk Failure

Mass Deploying Customized Windows 10/11 Installs

Building a GNU/Linux Based Windows Deployment Server

GNU/Linux Installer Server: Installation & Configuration

How to: Use (i)PXE to Install Windows from a Network

Why Memorize IP's When You Can Self-Host DNS Instead?

Ventoy - The USB Multi-Boot Utility!

Introduction to PXE/iPXE Network Boot Featuring FreeBSD & Ubuntu Server

 

Don't see what you need? Check the Full List or *PM me, if I haven't made it I'll add it to the list.

*NOTE: I'll only add it to the list if the request is something I know I can do.

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6 hours ago, Windows7ge said:

I remember back on X79 I had to O.C. my 3930K to around 4.2GHz to stop it from bottlenecking my two Radeon HD 7970's in CFX. If that metric is of any use to you.

I have a liquid cooler on my 4820k. What kind of temps were you seeing at 4.2 and what were you using to cool it?

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12 minutes ago, Frost Giant said:

I am using a i7-4820k. 16 GB ram on a MSI MS-7760 X79A-GD45 plus. 

Upgrade to e5 1650 v2 6 core or 1680 v2 8 core and overclock 4.5+, bclk might help with clocking the cpu higher for a given volt

 

Vcore wise intel 32nm spec is 1.55v but you wont get anywhere near that unless you got ludicrous cooling so stay under 1.4v and 85c

 

Using that kind of setup youll be able to power a 3060 with ease

 

Heck if you dont have enough money to spare then just ocing the balls off your 4820k will also suffice

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5 minutes ago, Frost Giant said:

I have a liquid cooler on my 4820k. What kind of temps were you seeing at 4.2 and what were you using to cool it?

You want me to remember back about 8 years? 😆 I remember having a Corsair H100 liquid cooler then moving up to full custom water cooling for the first time. I pushed the CPU up to 4.5GHz even though it wasn't needed but today you should be able to use any reasonable performing air cooler to achieve 4.2GHz and stay under 80°C. You might pull it off with the ever so cheap CoolerMaster Hyper 212 EVO.

Guides & Tutorials:

PROXMOX - Rebuilding ZFS RAID rpool After Disk Failure

Mass Deploying Customized Windows 10/11 Installs

Building a GNU/Linux Based Windows Deployment Server

GNU/Linux Installer Server: Installation & Configuration

How to: Use (i)PXE to Install Windows from a Network

Why Memorize IP's When You Can Self-Host DNS Instead?

Ventoy - The USB Multi-Boot Utility!

Introduction to PXE/iPXE Network Boot Featuring FreeBSD & Ubuntu Server

 

Don't see what you need? Check the Full List or *PM me, if I haven't made it I'll add it to the list.

*NOTE: I'll only add it to the list if the request is something I know I can do.

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