Unique issue

[Il_Burza]

Hello!
I'm having a unique issue.
I say unique because I don't seem to find this issue anywhere else.
For 99% of the applications I try to launch (including setup.exes) I get the blue box telling me "Impossible to execute the app on your PC. To look for a version for your pc, contact the software distributor".
Very few select applications seems to work.
So far of all the 6 TB of data, only skype, blender and google chrome seem to work. That's it. Not even setup.exe files. Some application seem to start but then stop working (Edge and premiere pro is one of those, I get the splash image, but then nothing happens, not even an error).
I already had a similar issue in the past, brought it to tech support, told me they didn't know what was causing it but that all the hardware seemed to work fine. They told me to whipe the pc and start with a new install of windows.
I did as told, that was last summer.
Everything worked perfectly until literally today where it all broke down.
I'm quarantened in Italy with no tv (choices of a world with working stores)
healp, plz.

[WkdPaul]

do you have a screenshot of that error?

[jj9987]

What system, what operating system?

[Brather_Brothersome1]

I have seen this before.

first do this

1. Change your registry

1. Press Windows Key + X to open Win + X menu and select Command Prompt (Admin) from the menu.
   
2. When Command Prompt starts, simply enter regedit and press Enter.
3. Registry Editor will now open.
   • In the left pane go to HKEY_CLASSES_ROOT.exe.
4. In the right pane, double click (Default) key and set Data value to exefile.
   
5. Now go to the HKEY_CLASSES_ROOTexefileshellopencommand key in left pane.
6. In the right pane select (Default), double click it and set its Value data to “%1” %*.
   
7. After doing that, restart your computer and check if the problem is resolved.

Not being able to open .exe files can be a big problem, but you should be able to fix it simply by changing your registry. For some unknown reason, the values in your registry can be changed from the default and that can prevent .exe files from opening.

Some users reported that this solution only works if you apply it in Safe Mode, and to enter Safe Mode you need to do the following:

1. Hold the Shift key on your keyboard and click the Restart button. Alternatively, you can restart your PC few times during the boot to start Automatic Repair.
   
2. Select Troubleshoot > Advanced options > Startup settings and click on Restart button.
3. When your computer restarts, a list of options will appear. Select any version of Safe Mode by pressing the appropriate key.
4. When Safe Mode starts, repeat the steps from above.

 

should that no resolve your issue do a DISM Online check the command is this it will validate the signatures of all your files against the latest image and restore those that are affected.  this is the command:

in a cmd as admin:

DISM /Online /Cleanup-Image /CheckHealth

 

let me know if it helped