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It depends on the width of the cards in question, but i'd say it's possible.

But something else about the Genome, the build quality is not quite there, if you catch my vibe.

I'd get something else plus a 240mm AIO for the price.

Project Diesel 5.0: Motherboard: ASRock Fatal1ty X370 Professional Gaming /// CPU: Ryzen 5 3600X  /// CPU Cooler: Scythe Ninja 5 /// GPU: Zotac AMP Extreme RTX 2070 /// RAM: 2x 16gb G.Skill Ripjaws V @3200mhz /// Chassis: Lian Li Lancool One Digital (black) /// PSU: Super Flower Leadex III 750w /// Storage: Inland Premium 1TB NVME + Toshiba X300 4TB

 

Peripherals: Mice: Cooler Master MM720 /// Keyboard: Corsair K70 MK2 SE (Cherry Silver), Blitzwolf BW-KB1 (Gateron Reds) /// Monitor: Acer XZ320Q 32' (VA, 1080p @240hz) /// AMP: Topping PA3 (Onkyo Integra A-817XD undergoing restoration) /// DAC: Weiliang SU5 /// Speakers: AAT BSF-100 /// Mike: Alctron CS35U /// Headphones: Blon B8, ISK MDH-9000

 

Living room: TV: Samsung QLED Q7FN 55' 4k /// Amplifier: Denon AVR-X2400H /// Speakers: DALI Zensor 7 /// Consoles: Sony PS4 Pro 1TB, Sony PS3 500gb /// LD/CD/DVD: Pioneer DVL-909 /// Power Supplies: Upsai ACF-2100T + GR Savage CDR2200EX

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It should work as long as the graphics card on the inside isn't too tall and the power cables aren't blocked. 

If you ever need help with a build, read the following before posting: http://linustechtips.com/main/topic/3061-build-plan-thread-recommendations-please-read-before-posting/
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