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Yes, lack of good power circuitry or the wrong PCI slot, like 4x instead of 16x.

Rofl, no. PCIe was designed to be interchangeable, so you can use a 4x card on a 16x slot, or a 16x card on a 4x without any problem.

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Yes if the mobo has a power surge or something. If a motherboard dies it can sometimes take parts with it too.

My Rigs:

Gaming/CAD/Rendering Rig
Case:
 Corsair Air 240 , CPU: i7-4790K, Mobo: ASUS Gryphon Z97 mATX,  GPU: Gigabyte G1 Gaming GTX 970, RAM: G.Skill Sniper 16GB, SSD: SAMSUNG 1TB 840 EVO, Cooling: Corsair H80i PCPP: https://au.pcpartpicker.com/b/f2TH99SFF HTPC
Case:
Silverstone ML06B, CPU: Pentium G3258, Mobo: Gigabyte GA-H97N-WiFi, RAM: G.Skill 4GB, SSD: Kingston SSDNow 120GB PCPP: https://au.pcpartpicker.com/b/JmZ8TW
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