Worth a fresh install?
Upgraded W10 to fresh install was worth it for me - I didn't have a whole lot on the drive and it took a little over half an hour.
System interrupts are hardware errors - I have one with a Broadcom driver not being present for my network card because Asus don't supply the driver for Windows 10. The card doesn't use that driver because this revision doesn't come with a Bluetooth radio and functionality so I'm not bothered.
My system interrupt percentage is 0.1% - and this accounts for that.
Make sure you have all the latest (whql) drivers for all your hardware and the support features your motherboard has if you want to lower that percentage.
Edit - I'd suggest opening your Event Viewer and looking through your Errors and Critical logs to see what devices are causing it.

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