Enabling Virtualization bricks the PC
Do you have a usb stick you could install an ubuntu image to, and see if it boots successfully to that with SVM enabled? If not, or if Ubuntu also won't boot, apparently some users with this issue appear to have success by disabling IOMMU or disabling secureboot. It's a slim shot, but try disabling any CPU or memory overclocks in BIOS as well. Have you unplugged any unnecessary peripherals and attempted to swap mice and/or keyboard?
I have a regular 3600 with the same motherboard (assuming we're both using the WIFI-less model), similar ram (2 x16 TridentZ RGB 3600 CL16) and a Samsung 970 Evo Plus 500gb (so also nvme ssd boot drive), and SVM works just fine. I'm using BIOS version 2812 according to CPU-Z, and I'm running Windows 10 Pro Insider Preview version 10.021301 (build 21301), so it's possible rolling back to this BIOS version might help. Some BIOS updates can't be rolled back, but it looks like the last one for the Tuf Gaming X570-Plus that doesn't allow rolling back is version 1404, so it appears to be possible*. I'm in the middle of a 5TB directory comparison, so I can't check my BIOS settings at the moment, but when I'm done, I'll gladly share my settings with the hopes it might help.
As to why this happens? It could be faulty hardware, as you mentioned, but it could also be a hardware incompatibility based on the BIOS revision or with Windows 10 (assuming Ubuntu boots). Hell, it could even be an errant ram stick or your boot drive. Those are unlikely, but I've seen strange behaviors in the past, both on my own and on other's systems.
*If you're using any Hardware RAID features, make sure the data is backed up, since I noticed some of the BIOS updates have updated hardware RAID features. It's possible rolling back and/or updating the BIOS could bork it. And technically, rolling back or updating any BIOS has the chance to brick, which I'm sure you know, but just putting it out there, in case someone reads this in the future.

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