Assuming this is a storage drive, pretty much all you have to do is move the files from one drive to another. If you have any Steam games on there you'll have to configure the new location of your Steam library, but everything should work pretty much flawlessly from there.
EDIT: Forgot to add: any applications with shortcuts from the original drive will need to have their shortcuts updated. You can do this by going into their folders, going to the raw executable and creating a new shortcut.