Optimizing Builds for Thread Ripper?

[SovietBroski]

So I have been ghosting these forums for years and I always see negative reactions to the build questions like, "I threw all the money at the things but can I run crysis?". I guess in a way this is me trying to learn how not to be THAT guy. My issue is that, whenever I look at a part in a vacuum I tend to gravitate towards the most expensive version out there. I mean sure I could get a dam fine motherboard for $100 USD but that $600+ version is just so much prettier! 

 

I am in the very early stages of planing and parting out my next build and the only thing I know for sure is that I want to run a Thread Ripper CPU. This computer is going to be a real work horse for all of my personal projects that range from 3D rendering, printing , and CnC milling, to audio/video editing/recording, to virtualization and thin client serving and of course gaming is on the menu as well. Not all at once obviously but the point is that this rig is going to wear many hats. I heard that a lot of the best/most expensive parts out there are not optimum when paired with each other which finally brings me to the root of my question. Setting aside the price-factor for a moment, how can you tell which parts pair nicely with each other and which ones create issues like unexpected bottlenecks and so on?