Multiple GPU's Not in SLI/Crossfire
1 minute ago, DioOmicida said:So example: You'd see almost negligible performance loss using a single card on two monitors, one running [generic AAA title] with a second monitor having a few browser tabs open, a skype call, [extended list]?
Not almost negligible, it is negligible. I spent a few hours testing the performance impacts of running various monitor setups and found no performance loss when running desktop, browser or other light applications, even when running an additional 4K and two more 1080p monitors. Running 1080p video has a small impact and 1080p Youtube takes up a bit more, however, that's likely to be down to CPU as well.
3 minutes ago, DioOmicida said:An example I know a lot of my friends do is to play League of Legends and between matchs run a game of rocket league.
I know those aren't taxing games but that's where the concept is coming from.
If it's different games, you can run multiple games at once anyway. If you wanted to dedicate it to one card, you can go into application settings in the Nvidia control panel and set a game to use one GPU or another (may be able to do it through the game). If you had each monitor on different cards, having the game in Windowed mode so it can be moved to the next monitor should switch which GPU is being used. I've not tried that myself, so I can't be sure on it.

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