Compatible
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Solved by Eigenvektor,
In general any modern motherboard is compatible with any PCIe graphics card. PCIe is backwards and forwards compatible.
Since the b460m only has PCIe 3.0, the GPU would run in backwards compatible mode (i.e. also PCIe 3.0). Since it only has 8 lanes, rather than 16, you'd be somewhat bandwidth constrained compared to a board that had PCIe 4.0 x8. In most cases that shouldn't matter though, at least for this GPU.

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