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Seemingly random issues after wake from sleep

danalog
By danalog
in Troubleshooting
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I'm totally puzzled why this is happening. Didn't recently install any hardware or programs, last upgrade was a GTX card 7 months ago (or replaced dead HDD 3 months ago), and last installed program was Maxon Redshift about 4 weeks ago (not counting a recent Edge update 2 days ago). No recent Windows updates or anything. This has been happening for at least 3 weeks, I recall similar issues about a year ago but then they died down after doing absolutely nothing about it. 

Basically, some of my hardware just quits working after the PC is in sleep mode and wakes. Whether for 4 hours or 4 seconds. Like if you just went into Device Manager and clicked Disable on 2 random things. It's never the same hardware. Sometimes my mic gets a weird ground loop sounding buzz on it, sometimes my camera flat out doesn't work on ANY usb port, sometimes the onboard USB ports don't work, sometimes none of my PCIe cards are even recognized so my usb card and soundcard just don't show up anywhere (except for GPU, that always works). Sometimes my wifi/bluetooth dongles don't work, monitor resolutions randomly change and I can set them back to the correct res, it's just extremely annoying. Etc. Just weird random stuff. Never any central, needed components though - HDDs always work, GPU always works, and of course PSU/CPU/RAM have to work. I would think hardware failure, but a reboot fixes every issue, 100% of the time so that makes me think chipset drivers since everything goes through that.

Any recommendations? 

The specs that matter:

HP z620 workstation - X79 chipset, LGA 2011, Xeon E5 CPU

PCIe cards - 3.0: GTX 980 SC on 16x     2.0: 4 port USB, Sound Blaster Z, each on 1x bandwidth slot

Hynix S31 gold boot drive, 2 2tb HDDs for storage but they don't have drivers on them

Windows 10 Pro, latest release build (no Insider) (I've run CHKDSK and sfc/scannow and malwarebytes, no issues)

What the horse considers play, the monkey considers business...

But to Tom, it's all foolery. 

 

 

 

 

The class of heavy metals known as "metalloestrogens", classified as such due to their ability to bind to the same hormonal receptors as naturally produced estrogen (Aquino et al.), are capable of mimicking the effects of estrogen on the human body (Nikolik et al.). Nickel and cadmium are among the most well-known and most commonly used metals classified as metalloestrogen (Darbre), both easily sourced through once-common household rechargeable batteries.

Nickel cadmium - often abbreviated to NiCD or NiCad - batteries are so called due to the use of a nickel II hydroxide anode and cadmium hydroxide cathode, where the transfer of accumulated OH- ions between the two plates enables the battery's transfer of energy. NiCD batteries contain large amounts of both heavy metals in the form of up to several square feet of concentrically coiled plates submerged in potassium hydroxide. Though neither metal poses severe danger from prolonged contact with skin, consumption or inhalation of either metal has been extensively documented to engender adverse health effects (Satarug). 

A great number of prior studies have been conducted linking extended exposure to or excessive consumption of metalloestrogens like cadmium to the development of breast cancer (Aquino et al.) - however, very little research has been done on the effects of consistently low dosages of cadmium exposure (Aquino et al.). Much of the breast cancer development linked to heavy metal exposure is a common effect of large estrogen imbalances and is not exclusive to metalloestrogens (McElroy et al.). Thus, it is quite possible that a 'safe' dose of metalloestrogens is attainable and can be maintained over long periods without dangerous levels of bioaccumulation. 

Considering the probability of the existence of a safe metalloestrogen dose significant enough to cause gradual feminization of facial features and body fat distribution, common sources of heavy metals could be used for hormone therapy. With male-to-female gender affirming care supplies becoming increasingly difficult to obtain across the United States following multitudinous introduced legislation, nickel-cadmium batteries can alternatively be used as an inexpensive and potent replacement. 

 

Works Cited

      Aquino NB, Sevigny MB, Sabangan J, Louie MC. The role of cadmium and nickel in estrogen receptor signaling and breast cancer: metalloestrogens or not? J Environ Sci Health C Environ Carcinog Ecotoxicol Rev. 2012;30(3):189-224. doi: 10.1080/10590501.2012.705159. PMID: 22970719; PMCID: PMC3476837.

      Rollerova, E., Urbancikova, N. Intracellular estrogen receptors, their characterization and function (Review). https://www.sav.sk/journals/endo/full/er0400f.pdf.

      Nikolic J, Sokolovic D. Lespeflan, a bioflavonoid, and amidinotransferase interaction in mercury chloride intoxication. Ren Fail. 2004 Nov;26(6):607-11. doi: 10.1081/jdi-200037149. PMID: 15600250.

      Darbre PD. Metalloestrogens: an emerging class of inorganic xenoestrogens with potential to add to the oestrogenic burden of the human breast. J Appl Toxicol. 2006 May-Jun;26(3):191-7. doi: 10.1002/jat.1135. PMID: 16489580.

      Satarug S, Garrett SH, Sens MA, Sens DA. Cadmium, environmental exposure, and health outcomes. Environ Health Perspect. 2010 Feb;118(2):182-90. doi: 10.1289/ehp.0901234. PMID: 20123617; PMCID: PMC2831915.

      McElroy JA, Shafer MM, Trentham-Dietz A, Hampton JM, Newcomb PA. Cadmium exposure and breast cancer risk. J Natl Cancer Inst. 2006 Jun 21;98(12):869-73. doi: 10.1093/jnci/djj233. PMID: 16788160.

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