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It shouldn't matter what form factor the hard drive is (laptop 2.5" vs desktop 3.5"), but it only supports one drive at a time (possible exception is if the drives are in hardware RAID, but that's just my personal guess, with no basis in fact or research)
"The chip giant has listened to customer feedback and is allowing Optane software to cache data from any single SATA hard drive in a system, regardless of it being a primary/boot or secondary volume!"

https://www.legitreviews.com/intel-optane-memory-tested-with-secondary-hard-drive_205254

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