No, the settings of a DOCP profile are stored in the sticks themselves.
You won't "Overwrite" them with any changes done in the BIOS, takes an actual SPD programming tool to do that and that's some really advanced stuff you'll probrably never even have to worry about or even see yourself.
The changes are held by the BIOS and will revert if you go back to defaults or just reset the BIOS.
As for disabling and reenabling, yes it goes back to the programmed defaults of the DOCP profile everytime you enable it.
If you change voltage from a DOCP default of 1.35 to 1.36 and then disable, then reenable DOCP it will reset voltage back to 1.35v's - At least it's supposed to but if the board's voltage options are set to manual it may not but I believe even with that it gets changed back to it's defaults.