Oh sorry I may have explained this wrong, I did actually screw in the card. My concern was that I had to put in more pressure than I've ever had to compared to previous builds to actually put the GPU into a position where I was able to actually screw it in. As I mentioned above, I had to live the GPU away from the motherboard and back towards the back of the case to be able to screw it in. Cables are plugged in already, GPU is installed and working.
Surprised I didn't see anyone touch on this.
The most common cause of this happening is a warped bracket, or even a not tooled correctly back panel. I had absolutely no problems (besides the weight of the card) screwing a RTX 3090 into my Fractal Design 7 XL case. Just needed a normal amount of nudging to get the thumbscrew screw holes lined up (It was no different than my r9 290X and my now dead Vega 64). This was on a Maximus 12 extreme motherboard.
I remember I had some serious difficulties with one of the screwholes on an AMD HD 7970 card with a Lian-Li PC-777B case however. Don't even remember if it was the card panel, case or motherboard position that caused it.