One of the strangest perhaps is "What Remains of Edith Finch". Almost brought me, a grown man, to tears. Spiritfarer is in similar in build up.
Mindustry is a good factory building game, also Dyson Sphere Program.
For the game mods - Archolos, Enderal - both brilliant, for Gothic 2 and Skyrim respectively.
In more general sense - The Witcher series and Fallout series.
But of course there are many-many small indie titles too...