Luke Murtagh

The more the merrier if u have the budget. But do try to setup ur airflow so ur not re-using warmed air, it reduces the efficiency of the rads using that warm air.
 
Ideally have each rad using 'clean' air. So in that case i personally would go with a 480mm in the top and a 280mm in the bottom and use the front for clean air intake.
Cant say im a fan of the case though, if u want big rad space i would go with something with more options. Like the cheaper priced Thermaltake Core X71. A 360mm rad in the top fed by front intake and a 360mm rad in the bottom with its own intake.
 
 

Yes, the only time u have to worry about mix and match in terms of manufacturers is when going with hardline tubing, as manufacturing tolerances can cause fittings and tube from different manufacturers to not be perfectly snug,
 
Also mix and matching aluminium and copper is a big no no ..so dont do that. (Galvanic corrosion)
 
Im also in the UK, u can try the following sites.
 
Overclockers.co.uk
Scan.co.uk
Aria.co.uk
Novatech.co.uk
Ebuyer.com
Amazon.co.uk
Watercoolinguk.co.uk
aquatuning.co.uk
CCLonline.com
 
Can also check out aliexpress if u dont mind going that route, also ebay.
 
TIP: check ebay for the above websites 'stores' as they can sometimes have cheaper prices. I have had this happen with Scan for example.
https://www.ebay.co.uk/str/scancomputersoutlet

It should be fine as long as you don't mix copper and aluminum parts.

Corsair is new the scene and they have a few issues to sort out, especially with their GPU blocks.
 
Out of the 2, EKWB is the better bet.
 
However dont limit urself just to EK, there are plenty of other manufacturers , like Hardware Labs, they make arguably the best radiators. And Bitspower who arguably make some of the best fittings, and Barrow and Bykski whom make some very good budget waterblocks (i use a Barrow one myself for my 1080ti, and a EK block for my CPU).

Yes, good point, fair enough. That is indeed the card I have. 
 
I doubt I will need it, as I would rather slightly scale back my overclock than add that AIO.
 
Thanks again for all your help!

If you plan on adding your own fans to the case. The Meshify S2 only comes with two 140mm fans *at the front*, which will almost always lose to two 200mm fans in an air cooling scenario unless very poorly positioned. Keep in mind all of that testing is done with stock fans at stock locations, so replacing the front fans with better ones in the S2 can help you get better temps, but it's not guaranteed to be better than the Mastercase H500 series. 
 
If temperatures are your highest priority in deciding between these two cases, go for the H500M, as you might have to spend more on the S2+fans to match or exceed the H500M in airflow potential.

Thanks for the help! I’ve seen people with very similar setups to mine on PCPartPicker and their temps are no higher than 70 degrees for CPU and GPU which seems decent.
 
If I may ask one more question: what would do a better job of cooling my CPU? My current Noctua or a similar air cooler such as a Dark Rock Pro 4 or an AIO?

Yeah, my PC is going next to my desk on top of a TV stand until I get a proper setup. I think in all honesty I prefer the looks of the S2 as the C just looks... a bit short. The extra length of the S2 does look better imo.