multiple graphic cards Using 2 different Graphic cards
I use a GTX 780 Ti and a Radeon RX 480 in my system at the same time. I run the system using the 780 Ti and use the RX 480 for OBS recording since the NVENC encoder on the 780 Ti does not handle 1440p above 30 fps. Recording images produced by the 780 Ti using the RX 480 encoder with OBS does work just fine though, which is cool.
I just installed drivers for both, no tricks needed. The cards seem to be deactivated though if you do not have monitors plugged into them. If all my monitors are plugged into the GTX 780 Ti, the Radeon control panel will not open ("No AMD graphics card detected") and attempting to record OBS using the AMD hardware results in about 1 frame per 3 secconds, and no VRAM usage on the 480 (usually it's around 3 GB when recording). And vice versa if I plug everything into the AMD card and try to record using the 780 Ti. NVIDIA control panel will not open (no NVIDIA hardware installed), and so forth.
So I run one of my auxiliary monitors from the RX 480, and both control panels are accessible and recording on either works fine.
In terms of feature support, you can't "combine" things like FreeSync + NVIDIA DSR or something like that. Features available will vary per monitor and will not be available at the same time on the same monitor. I can use NVIDIA DSR or anything else in the NVIDIA control panel on any monitors plugged into the 780 Ti, and I can use FreeSync and such on any monitors plugged into the RX 480. But if you game on a GTX 1080 or something, and want to stick an RX 480 in the slot below it to "unlock" FreeSync capability or use PhysX with an AMD main card by sticking a cheap NVIDIA card in below it or something like that, it doesn't work like that. You can make these features available if you plug your monitors into that card, but your FPS in games will be determined by that secondary card. Whichever card the monitor is plugged into is the card that renders the images for that monitor.

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