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No. The screw placements are different. You can buy a hot-swap tray if you have a 5.25" bay.

Cor Caeruleus Reborn v6

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19 minutes ago, CptLameJokes said:

It highly depends on your case. Mine 3.5" can hold every standard 3.5" and down, my 5.25" can hold anything 5.25" and down. 

 

If the screws are in the standard position, I don't see why you can't.

Thanks for the reply, very helpful and appreciated

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