Questions about MDF
If you use screws, make sure you pre-drill or it will likely split and swell, the thinner it is, the more likely it is to happen. I use screws with 3/4" MDF and rarely have a problem, but 3/8" would be near impossible. Better yet than screws would be to use cross dowels like this, but again the thinner it is the harder it will be to come up with the proper hardware:

Never use water to seal MDF, it will cause it to swell. I've used both oil based poly, and oil based paints, both work fine. They sell a oil poly in a spray can that is really easy to use for small jobs.
Honestly though, MDF isn't a very good material for building a computer case, not that I can come up with a better option for you...
I wouldn't use MDF for a desk personally because they tend to sag after a while and they're just not as sturdy as plywood, for example.
He is talking about a computer case. MDF is actually an excellent material for a desk, yes it needs braced, but so would plywood. MDF is much less prone to vibrations due to the density of the wood, and it is also much more dimensionally stable and consistant, it is also well suited for contact cementing laminate tops to it. I personally use plywood for nearly everything just because I don't like dealing with the dust of MDF, but we built a 10' by 6' conference table for our shop out of two layers of MDF and 5 years later even the wings with 3' of unsupported overhang are not sagging.

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