As a software developer, there would have to be a huge incentive for me to go off intel. A lot of the developer community would have to make a great push to support AMD, even though they use the same instruction set. Things like JavaScript and (pure) Python shouldn't be too much of an issue, but there is an insane amount of precompiled libraries out there (which I use everyday) which have too many issues with non-Intel. This is ultimately the biggest roadblock AMD will have