Yes it works, I added a G10 with H75 cooler to my 780 ti in my 250D, which already had an H100i for CPU.
The H75 (with push pull 120mm fans) sits where the front case fan would be, and the hoses had to be routed over the top of the video card (instead of through the G10 bracket) and the pump/block is mounted 90 deg counter clockwise from how it would normally sit, to accomodate the alternate routing.
Yes, it's tight, but it all fits and temps are cool.
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