Knurd

I'd grab an H170 or a B150 mobo, preferably ASRock or ASUS. Gigabyte is a good alternative.
 
For CPU, I'd personally go with the i7 6700 if you're going to be doing productivity tasks like you say. An i5 6600 or 6500 would work fine, but a 6700 would give you a better experience and more longevity.
 
As for RAM, go with at least 2666 Mhz DDR4. Corsair, G.SKILL, and Crucial make solid RAM. Get at least 16 GB.

If it's just for what you described, the i5-6500 is a decent processor. I don't personally see any reason to get anything above that. AMD is great for budget, but IMHO an i5 will suit you better. LGA 1151 motherboards are fairly cheap, and DDR4 prices have fallen fairly nicely in the past few months.

It's just user preference. You'll have to upgrade the i5 marginally sooner, as it obviously isn't hyperthreaded like the i7. I don't know about more efficient... I think the TDP is fairly similar on the two chips, IIRC.

For Illustrator, maybe. Photoshop, no. It depends on your workload.
 
Like I said, the i5 6500 would be fine, but the 6700 would be the optimal choice. With the i5, you'll probably wind up exploring CPU upgrades within the next 2-3 years, whereas with an i7 you'll get an extra year or so of good use on top of that 2-3 year estimate.
 
I've had my i7 2600k for nearly 5 1/2 years and only now is it beginning to feel a bit long in the tooth, even with a substantial overclock. Therefore I'm currently planning an enthusiast build centered around either Intel's 8 core Skylake-E CPUs coming out sometime in 2017, or AMD's Ryzen 8 core CPU.

^

The i5 4460 is definitely getting a little dated, especially for high end tasks like high quality settings in games and productivity. That being said, it's still sufficient for the majority of tasks, so you would not notice any bottlenecking except in a few games and particularly heavy workloads.
 
However, for more longevity and a better experience, I'd say you should upgrade.

A 4460 is fine for what you want to do even if it won't give you the absolute maximum from your 480. If you still want to upgrade, an i7 is the only thing that makes sense. I wouldn't buy a new platform though. Get an i7 4790 or 4770.

You won't get any bottlenecks in gaming, the 4460 is still a very capable cpu and won't bottleneck the rx 480. If you want to upgrade go with an e3 123x v3 or i7 47xx, whichever is cheaper.

4790K, if you're going to go that route. I just upgraded from that to a 6800K because I do content creation. It's a kickass CPU.

http://www.newegg.com/Product/Product.aspx?Item=N82E16814131697&cm_re=red_devil_480-_-14-131-697-_-Product
 
Always look out for the SKU that has a V2 on the end. 8GBD5-3DHV2/OC

It puts unrealistic stress on the card that will never happen in ANY other scenario. The reason I tell you to avoid is because I don't know if the card has the same VRMs as the original Red Devil 480 which would actually blow up if you ran FurMark on them because they were poor quality.

The cooler is different, but we have no idea if the PCB is any better. The Red Devil cooler is better so the likelihood that the Red Dragon has better PCB components is very low.

Yes, for normal everyday use, its' fine. It's just that a lot of PC gamers like to bench their GPUs with FurMark. That's where you will run into problems.

Then go ahead and get it.

I don't own that exact model but I can tell you that it'll be be able to achieve at least 45fps on 1080p.