So I was doing some preliminary benchmarking with my RX 480 eGPU. I ran Unigine Heaven at with OpenGL, at 1440x900, on Ultra, 2x AA with no Tessellation.
So as you can see, the x4 PCIe configuration and latency of Thunderbolt 3 cripple any GPU you put in it. Of note is that the fan on the 480 hardly gets to ramp up. Probably because so much of it's potential is wasted with Thunderbolt overhead.