In my personal opinion i think that it would be possible but i have concerns about the GPU's Memory, is 3,5 GB even effective for 3x 1080p and 1x 2160p? In situations like this i would rather get the 390x 8gb but thats my opinion, i see it as possible if you disconnect the other 3 monitors when you are playing but even if you do that i have concerns for general usage so yeah, i'd personally get a 390X but, the final decision is with yourself