It's quite simple.1. Use 7-zip to copy the contents of the ISO to a USB drive that is 5GB or larger.
2. Copy a file named bootsect.exe from the boot folder into C:\Windows\system32.
3. Type cmd into the Start Menu, then press Ctrl+Shift+Enter
4. Accept the UAC prompt
5. Run the command 'bootsect /nt60 E:", replacing E: with the drive letter of your USB.
And there you have it. Now you have a USB that can install both Windows 10 Home and Pro into BIOS and UEFI machines.