Oh... well depending on the refresh rate and latency, going back and forth, if the same latency and refresh rate are the same it will be fine, but if not the same, it do well.
It really depends on what you're doing. if you're gaming on one screen and doing productivity on the other, the different ifs fine,
But if you want to sync the monitors so you can go full screen, it wont look good.
Normal productivity will be fine with different monitors, but if you want to game, i suggest playing on one and doing something else on the other.