Plenty of room for cooler (asrock z97/ac, r5, nd-d15), but low profile ram is best if you are using both fans and don't want to raise the side fan too high above cooler to clear ram.......I dont see how any motherboard could be an issue unless its freakish in some dimension.
You should check out the noctua nh-d15 faq/specs and the r5 manual on both websites they provide exact dimensions for clearances etc