Created an account just to respond to this, because I'm in a similar situation, have similar opinions and haven't seen much discussion anywhere yet. My main issues are a combination of performance and aesthetics.
Compared to the Define R6:
Good
Solid top cover is slick as hell.
Two separate purpose-built top covers (airflow vs noise reduction) is a fantastic idea.
Modular plastic cover means no more gaping hole in the PSU shroud when using the "open" format.
Improved cable management features on the rear of the motherboard tray.
More conveniently located fan controller.
Lower GPU temperatures (-3.6C under prolonged stress, Gamers Nexus).
Better side panel mounting mechanism.
Removable top mounting bracket for radiators makes getting at the inside of the case easier.
5.25" drive bay area is more modular and the cover better optimised for airflow, allowing more flexible fan or radiator positioning.
More storage options, including a 3.5" drive cage beneath the PSU shroud.
No RGB.
Ambivalent
Different feet. I like that the material blends in to the rest of the case more, but the new shape is a bit odd.
Louder acoustic performance (+0.8dBA with the door closed, Gamers Nexus). This is undoubtedly a lot more important for someone working in audio, but for the average person this is barely (if at all) noticeable and the difference may well simply be within the margin of error in measurement.
Bad
Higher CPU temperatures (+6.5C under prolonged stress, Gamers Nexus). I suspect at least some of this might be due to the default fan configuration, in which a large portion of the top front fan is occluded by the 5.25" drive bay bracket. Gamers Nexus even call this out in their review, but don't follow up -- would love to see further testing on this.
The dust filter pattern. It's irregular, it's ugly, and looks as though it would be both less efficient at admitting air into the case and harder to clean than a standard grid pattern. The way the top dust filter layers with the airflow-oriented top cover is very chaotic, visually.
The cutout pattern. For a brand that has previously prided itself on the subtle, reserved aesthetic, this looks positively garish. I could live with the pattern as applied to the rear and bottom of the case, as they're both consistent and rarely visible. But for the PSU shroud and airflow-oriented top cover they've filled in parts of the cutout pattern at random. The human brain is very good at seeking out and detecting patterns, and introducing a chaotic element into a geometric design like this is frustrating to look at, because your brain can't "solve" the pattern. I might be overreacting, but it's a bizarre choice and would probably prevent me from wanting to use the tempered glass side panel or the airflow-oriented top cover.
There's so much to love about the improvements to the Define 7, but the poorer thermal performance and weird aesthetic choices have me leaning toward snapping up a Define R6 before they disappear from the market as well.