Well it obviously wouldn't be very cost/space efficient (as you would need an extra pump, reservoir and possibly radiator).
JayzTwoCents has made a video on loop order though:
So here’s the skinny.
Lian Li Tu-100
6700k
270 Gaming 5 itx
H60 AIO
RX580 V1 (shortbus version)
Custom loop with fuel line from Lowe’s
Swiftech Micro Rez 2
Noctua 120x15mm x2
Silverstone 450 sff psu
Gskill 32gb (2x16gb)
1 very janky cable from China that converts m.2 to pcie x1 with power from 4 pin molex for the WiFi and Bluetooth card
fenvi t919 (hackintosh special)
i built this little guy to see what all I could cram into this handled case.
Lian Li hit a real homer in with this design.
I see people singing it’s praises nowadays but a couple years ago TU-100 was a bit of a black sheep.
Theres more then a few people who found it necessary to Frankenstein this case for the sake of air flow.
All I did was punch a whole in the bottom with circle saw and remove the front end internal scaffolding.