Sure, why not. Here's my work in progress. I'm here because of the video.
It's not an iMac. It was at one point.. someone killed it. I bought the frame, repaired it.. bought glass for the chunky 2010 iMac and build in a new monitor, an apple tv, and a stereo amplifier into the frame..
It uses the original power cord for power, and I'm currently in the process the get my hands on some original IO ports to use the displayport and the ethernet for the internals.. maybe the audio jack as well.. but my current stereo amplifier does not support it. Maybe upgrade to USB-C... who knows..
DO NOT attempt to do this on a 21.5" iMac as I did by mistake. It is close to impossible to get stuff to fit in there. Apples engineers did some magic there to fit the parts.
Still some work to be done on it. But it's a pretty decent monitor.. with some features.
Initially wanted to build in a graphics card... but it's not a 27".. and, yeah.. it was not even remotely possible.