No, not at all.
The only downsides is slight ghosting (only visible in UFO test)... and hey, some games even have "motion blur" effect which requires GPU computation!
You'll get a tiny bit of that for free! During gaming, you'll be stunned by the deep black colour instead of ugly gray, more colours etc..
And about 3 of the millions of pixels are dead.
I looked for them by putting yellow / green / red / blue / white / black... images on the screen. I didn't notice them during normal use.
I was also hesitating between AOC and ASUS monitors, but since I already have a MSI GPU and motherboard, I gave them the chance again. They didn't fail ^^