I just built a new system, the CPU seems to overclock very well, 4.45 at 1.3v (see too high but stable) The RAM will run xmp, however adjusting any of the timings manually results in cpu debugging LED. I have to clear CMOS to boot. Didn't have any issues like this on my previous build.
(Not a clean install of Windows 10, from last build, x370 r5 2600. Updated chipset drivers)
R5 3600
B450 tomahawk (latest bios)
Corsair vengeance lpx 3200 cl16 (Samsung B-die)
Vega 56
Evga 700 watt bronze PSU