Have you checked temps on your CPU? Perhaps removing and remounting the cooler?
Also, if you are using XMP, try disabling this initially. If that works, try a lower speed for your ram, or looser timings than the ones the XMP suggests. Technically the CPU only supports up to 2666MHz, so you might just have a poor memory controller if you are using XMP to go above this.
Then obviously, there's things like reinstalling your game(s), checking drivers are up to date, etc.