Should work fine. It's an x58 platform and I ran a 1080 on mine until I upgraded it to a Ryzen. AFAIK a 1080ti might just saturate a x16 PCIe 2.0 slot, but not by much. Still you'll get a lot more processing power at lower power consumption - by the looks of the performance spreadsheet that keeps going around it looks like you'd get double the PPD for lower wattage with a 1080ti.