I love your comment, Asking all the questions that need answers. Firstly, yes, the system will be able to run air cooled, I just wanted to make sure that it was water cool accessible, since I want this case to sacrifice nothing! Secondly the GPUs will, most likely, be mounted vertically. I've looked at the current gen models, Nvidia RTX 2080 ti FE, KingpIn, Msi Lightning Z, Radeon VII, ext. The large gaming GPUs. The case will be able to support anything as big as, or smaller than those cards. Sketching up a side view of the case, I found that if we leave 5'' clearance where the dip at the front of the case is, we'll be able to house a 3 wide 120mm fan radiator. Which would mean if you left it air cooled, you could fit 3 120 mm fans on the left side, intaking air, blowing it from left to right, to exhaust the air with outtake fans. And of course, out the back of the GPUs. As for cable management, there will be a compartment underneath the board to be able to run everything nice and neat to the PSU. Me and my brother are currently trying to get some mock ups, but our budget is limited to free cardboard we got from the local supermarket. One of us, doesn't work do to ailments, while the other is saving for his wedding.