Sorry to necro..
I have a Meshify C with a front mounted 280mm EVGA rad and when gaming its causing the fans on my GPU to hit 2700RPM and screem.
On my old setup which was a Corsair 350D case with the rad mounted at the top the GPU was silent even under full load.
Checked a few vids on Youtube, the LTT one had the fans set to 60% which I think would put them about the same as my new setup i.e screaming along so not sure about that one.
The one thing I did notice is they all used standard length cases and the front rad was a lot further away from the GPU than mine, its almost touching for me, I am thinking this is making a big difference?