Hey there KhaosKutsune and welcome to the community Do follow your own topics so you get notifications whenever someone replies or needs more information in order to help you.
Some motherboards disable certain SATA ports because they are replacing them with the M.2 port for the SATA controller. You should still be able to use the ports that are not disabled with no issues. If you have trouble doing that feel free to contact the manufacturer of the motherboard for some assistance.
Feel free to ask if you happen to have other questions
Captain_WD.